 The World Health Organization has recently identified three categories of pathogens, namely critical, high, and medium priority, according to the need for new antibiotics. Critical priority pathogens include carbapenam-resistant microorganism, CPO, such as acinetobacter bamanii and pseudomonas aeroginosa, clebsiella pneumoniai, and enterobacter species, whereas vancomycin-resistant enterocacus fissium, VRE, methicillin and vancomycin-resistant staphylococcus aureus, MRSA, are in the high priority list. We compared the trend of antimicrobial resistance, AMRs, in clinical isolates, divided by year and bacteria species, of samples obtained from nosocomial and community patients. Patient records were collected, including age, sex, site of infection, isolated organisms, and drug susceptibility patterns. From 2019 to 2022, a total of 113,635 bacterial isolates were tested, of which 11,901 resulted. This article was authored by Paula Serrini, Francesca Rita Maduri, Flaminia Tomassetti, and others. We are article.tv, links in the description below.