 This study examined several methods for delivering RNA interference, RNAry, to treat hepatitis B virus, HBV. The researchers found that a combination of AAV8 vector and a decoy RNA, 2D, was most effective at reducing HBV levels without causing any serious side effects. This combination could potentially be used to develop a safe and efficient treatment for HBV. This article was authored by Thomas Mikler, Stephanie Gross, Stefan Mockenhaupt, and others.