 The study demonstrates the synthesis of cadmium sulfide, CDS, and zinc sulfide, ZNS, nanoparticles with antimicrobial activity against oral pathogens. The process for synthesizing CDS and ZNS nanoparticles is fast, eco-friendly, and novel. Formation of the nanoparticles was confirmed by surface plasmon spectra using UVVis spectrophotometer. The morphology of the crystalline phase of nanoparticles was determined from TEM and XRD spectra. The average size of CDS and ZNS nanoparticles was in the range of 10 to 25 nanometers and 65 nanometers, respectively, with a spherical shape. Proteins containing amine groups played a reducing and controlling role during the formation of CDS and ZNS nanoparticles in the colloidal solution. The sulfide nanoparticles exhibited good bactericidal activity against oral pathogens such as Streptococcus sp, Staphylococcus sp, Lactobacillus sp, and Candida albicans. This article was authored by C. Malakadi, S. Rajesh Kumar, K. Paul Kumar, and others. We are article.tv, links in the description below.