 Dry eye disease, DED, is caused by a combination of factors including reduced tear film stability and hyperosmolarity resulting in discomfort and visual compromise. It is driven by chronic inflammation and is influenced by the environment and bodily cues. This leads to an increase in tear breakup time, osmolarity changes and reduced tear film volume all of which are indicative of DED. Tear film abnormalities are exacerbated by inflammatory signaling and the secretion of inflammatory factors which attracts immune cells and contributes to the diseases progression. Cytokines and chemokines are released into the tear film and can be used to measure disease severity and plan treatment strategies. These include interleukins IL-1 beta, IL-2, IL-4, IL-6, IL-9, IL-12, IL-17A, IFN gamma, TNF alpha, chemokines, CCL-2, CCL-3, CCL-4, CXCL-8, Matrix metalloproteinus-9, MMP-9, VAST. This article was authored by Nimesha Akumar, Macharaju Praveen, Raghav Narsinghan and others. We are article.tv. Links in the description below.