 Restless leg syndrome, ILS, is a neurological disorder characterized by an urge to move and uncomfortable sensations. It has been linked to genetic variations in several genes, including mice 1 and BTBD9. In this study, researchers examined how these two genes interact in kinohobditis elegance worms and found that when one gene is missing, the other can compensate for its absence. They also studied mice with both genes removed and found that they had an earlier onset of motor deficits than mice with only one gene removed. These findings suggest that mice 1 and BTBD9 may work together to control RLS symptoms. This article was authored by Shangru Liu, Appenduruchi, Yisheng, and others.