 The study found that exosomes derived from disease-condition serum-primed immortalized human adipose tissue-derived mesenchymal stem cells, IMSCs, can alleviate cartilage damage in aromatoid arthritis, IA, model by enhancing TGF1 production, inducing TH2 and M2 polarization, and lowering pro-inflammatory cytokines. The study suggests that patient-derived serum can be used as an IMSC priming strategy in IMSC-derived exosome treatment of RA. This article was authored by In What Choi, I Rang Lim, Ji Hong Park, and others.