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Published on Jan 31, 2011
Dr Aubrey de Grey is Chief Scientific Officer of the SENS Foundation. His research interests focus on the accumulating, and eventually pathogenic, molecular and cellular side-effects of metabolism ("damage"). This "damage" constitutes mammalian aging and Aubrey's work seeks to design the interventions necessary for its repair and/or obviation. He has developed a potentially comprehensive plan for such repair, termed Strategies for Engineered Negligible Senescence (SENS), which breaks the aging problem down into seven major classes of damage and identifies detailed approaches to addressing each one.
A key aspect of SENS is its potential to extend healthy lifespan without limit, even with repair processes which remain imperfect, as the repair only needs to approach perfection rapidly enough to keep the overall level of damage below pathogenic levels. Aubrey has termed this required rate of improvement of repair therapies, "longevity escape velocity".
In 2007 Aubrey published his book, "Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime", bringing his ideas to a wider audience.
This presentation provides an up-to-the-minute survey of important developments in the programme to attain the human longevity escape velocity.