 This study proposes a novel approach to treating cancer by combining photodynamic therapy, PDT, magnetic hyperthermia and immunotherapy. Nanoparticles called Janus nanobullets were developed which contain both photosensitizers and magnetic materials. These particles can be targeted to tumors and then activated using light or heat depending on the type of nanoparticle used. Once activated, they can also generate heat which can be used to kill cancer cells. Additionally, these nanoparticles can trigger an immune response, making them ideal for use in immunotherapies. By combining this approach with immunotherapy, it may be possible to treat even advanced cases of cancer. This article was authored by Jing Wang, Fan Zhang, Dan Xiao, and others.