 In this study, it was found that idiopathic steroid-resistant nephrodic syndrome, ISRNS, and Egyptian children can be attributed to three main diseases, focal segmental glomerulus sclerosis, FSGS, minimal change glomerulopathy, NCG, and IgA nephropathy. In addition, mesangelohypercellularity and severe tubular interstitial disease were found to be the cause of steroid resistance in NCG and IgA nephropathy, respectively. Therefore, renal biopsy with electron microscopy examination should be performed on all children with nephrodic syndrome at their first presentation in order to properly assign them to appropriate treatment protocols. This article was authored by L.M. Ibrahim Sif, Iman Abdul Salam Ibrahim, Nadia Gailal El-Hefnoui and others.