 Pipettes are a necessary tool in any laboratory. Unfortunately, they're often stored improperly, handled roughly, and generally poorly taken care of. These simple misuses can lead to data that is unreliable and not reproducible. Thankfully, by adopting a few easy habits into your routine, your pipettes can serve you well for years to come. It's important to make sure you store your pipettes in an upright and vertical position. Note when your pipettes have been mishandled or misused and have them serviced when needed. Have your pipettes regularly cleaned and calibrated, either by yourself or through a company. To calibrate your pipette, use samples at the same temperature as the liquids you will dispense later. Colder liquids are denser than warmer liquids. You'll need a pipette, tips, roughly 5 milliliters of distilled water, a thermometer, a balance capable of measuring micrograms, weight boats, and a container for the water. Check your water temperature, pre-wrench your pipette tip, and immerse the tip 2-3 mm into the liquid. Pipette the liquid into the boat, weigh it, and then repeat the procedure. Weigh the largest and smallest amounts the pipette can dispense. Calculate your results, then find the average and multiply by 10 to get accuracy. Aim for a value of 99-101%. By incorporating these procedures into your daily lab routine, you can be more confident in the reproducibility of your data.