 Abstract hyphen thebaeca fruits were used to synthesize spherical erbium oxide nanoparticles, HT-R203NPS. These particles exhibited a crystalline structure, with a crystallite size of 7.5 nanometers, and a bound gap of 5.25EV. The physical chemical and morphological properties of the nanoparticles were characterized by Raman spectroscopy, reflectance spectroscopy, SAED, and HRTEM. The nanoparticles showed strong antioxidative activity and inhibitory effects against glucosidase and amylase enzymes. Furthermore, they also demonstrated significant hypoglycemic effects in diabetic mice. This article was authored by Hamza El Sayed Ahmed Mohamed, Ali Talha Khalil, Kaulah Khiri, and others.