 The study aimed at understanding the molecular pathways of liver tumouragesis and developing a chemical screening tool for anti-cancer drug discovery by evaluating the roles of several major signalling pathways in CRASv12 or mic-induced liver tumours using small molecule inhibitors. The results showed that VEGF-FGF signalling was required for both mic and CRASv12, induced liver tumouragesis, while WNT signalling was only required for mic-induced liver tumouragesis. Hedgehog signalling did not suppress either CRASv12 or mic-induced tumours. The suppression of liver tumouragesis was accompanied by a decrease in cell proliferation and an increase in apoptosis with distorted liver histology. This article was authored by Chuangyang, Qiqi Yang, Xiao Jinghua, and others.