 These, dear friends, is in my mind the journey that science now offers, that the Anthropocene plus the Garden of Eden plus the inside of tipping points leads us to planetary boundaries. We need a new framework. We need to ask ourselves how can we stay in a Holocene-like condition? What are the processes that really regulates the state of the Earth's system? And what are the quantitative science targets that can give us a boundary that provides us a safe operating space within which we can have safe and just future for humanity on Earth? And that's what led to the Planetary Boundary Framework. You've seen it perhaps. It is a guide to be able to kind of chart our future at the global scale, but increasingly also being adopted by businesses and countries around the world as a framework to be able to go beyond climate, to really recognize, just like Vicki pointed out, it's equally important with land, with water, with biodiversity, nitrogen, phosphorus, the stratospheric ozone layer and chemicals. We have to have a systemic, integrated approach with the new frontiers represents so eloquently.