 In this paper, we review and discuss 10 common methodological mistakes found in retrospective chart reviews. The retrospective chart review is a widely applicable research methodology that can be used by healthcare disciplines as a means to direct subsequent perspective investigations. In many cases in this review, we have also provided suggestions or accessible resources that researchers can apply as a best practices guide when planning, conducting, or reviewing this investigative method. This article was authored by Vassar Matt and Holzman Matthew.