 Obesity is a growing global health concern with direct and indirect effects on many aspects of health. It is associated with increased risk of developing several diseases such as diabetes, hypertension, liver disease and certain cancers. Additionally, it is linked to renal dysfunction which can further reduce life expectancy. Weight loss can help mitigate these effects by reducing hyperfiltration in obese individuals, suggesting a potential therapeutic option. This article was authored by Aravind Chandra, Michael Beersmith and Rameen Taliyan.