 Over the past 60 years, the semiconductor industry has been the core driver for the development of information technology, contributing to the birth of integrated circuits, internet, artificial intelligence, and internet of things. The semiconductor technology has been evolving in structure and material with co-optimization of performance power, area cost, until the state-of-the-art sub-5NM node. Two-dimensional, 2D, semiconductors are recognized by the industry and academia as a hopeful solution to break through the quantum confinement for the future technology nodes. In the recent 10 years, the key issues on 2D semiconductors regarding material, processing, and integration have been overcome in sequence, making 2D semiconductors already on the verge of application. In this paper, the evolution of transistors is reviewed by outlining the potential of 2D semiconductors as a technological option beyond the scaled metal oxide semiconductor field-effect transistors. We mainly focus on the optimization strategies of mobility, mu, equivalent oxide thickness, eot, and contact resistance, RC, which enables. This article was authored by Fulingua, Jiawu, Beihongli, and others. We are article.tv, links in the description below.