 This study found that university students are divided when it comes to being vaccinated against COVID-19. Those studying health and natural sciences were more likely to be vaccinated than those studying social sciences. Factors such as gender, age, opinions about lockdowns, and use of less reliable sources of information were also associated with vaccine hesitancy. Improved health literacy and trust in relevant institutions could help reduce vaccine hesitancy and promote effective prevention of COVID-19. This article was authored by Mario Marendek, Diana Aranza, Ivan Aranza, and others.