 Poly and isopropylacrylamide, PNIPAM, hygrigils are being increasingly used as vehicles for delivering active molecules, tissue engineering, regenerative medicine, and cell encapsulation due to their unique properties such as tunable mechanical properties, temperature-dependent swelling behavior, and high water content. These properties can be further enhanced by incorporating other polymers such as poly, ethylene glycol, PG, and or poly, epsilon caprolactone, PCL. Additionally, biopolymers such as collagen and hyaluronic acid can also be used to improve the biocompatibility of these hygrigils. Finally, advancements in three-dimensional bioprinting technology will enable the development of new devices and medical tools with thermal stimulus response needs, fabricated with PNIPAM hygrigils. This article was authored by Sonia Lanzalaco and Elaine Armelin.