 The key pathophysiological features of sickle cell anemia include increased production of red blood cells due to compensatory erythropoiesis, resulting in reduced levels of oxygen delivery to tissues, and chronic inflammation and vascular damage leading to impaired tissue development and function. The researchers hypothesized that sickle mice fed a high-protein diet would have better body composition, bone mineral density and grip strength than those fed a standard diet. To test this hypothesis, male-barclay transgenic sickle mice were fed either a 20% or 35% protein diet for three months. The results showed that the sickle mice fed the higher protein diet had greater increases in grip strength, body composition, and bone mineral density than those fed the standard diet. Furthermore, the addition of l-arginine to the 20% protein diet resulted in even greater improvements in these outcomes. These findings suggest that a high-protein diet may be beneficial for improving body composition, bone mineral density, and grip strength in sickle mice. This article was authored by Patrice L. Capers, Hyacinthi Hyacinth, Shaila Q, and others. We are article.tv, links in the description below.