 This study examined the effects of prenatal cannabis consumption on the epigenetic profile of the placenta and fetus. It found that prenatal cannabis consumption was associated with differential methylation of 581 CPG sites in the placenta, with 573 of these sites being linked to genes related to autism spectrum disorders. Additionally, the placenta showed the highest enrichment of genes related to autism spectrum disorders compared to other tissues. This suggests that prenatal cannabis consumption could be associated with increased risk of autism spectrum disorders in offspring. This article was authored by Lindsay Eshoi-Kendrick, Victoria H.J. Roberts, Rahul J.D. Mello, and others.