 This study investigated the efficacy of a novel vaccine for COVID-19, called DNS-1-RBD. This vaccine was found to be effective against multiple strains of the virus, including those that have evolved since the initial outbreak. It also reduced the severity of symptoms and decreased the amount of virus present in the body after exposure. Additionally, it reduced inflammation and prevented overactive immune responses which can cause further damage to the body. These results suggest that this vaccine could provide broad-spectrum protection against all strains of the virus, making it an important tool in the fight against COVID-19. This article was authored by Liang Zhong, Yao Jiang, Jin Hang He, and others.