 The use of herbal medicinal products and supplements has increased significantly worldwide, with many people relying on them for primary health care. Despite promising potential, many herbal products remain untested and their use is poorly monitored. This lack of knowledge about their mode of action, adverse reactions, contraindications, and interactions with existing medications can lead to safety concerns. To address these issues, regulatory authorities must ensure that all herbal medicines are safe and of suitable quality. This review discusses toxicity-related issues and major safety concerns associated with the use of herbal medicinal products and highlights challenges in effectively monitoring their safety. This article was authored by Martens Eker.