 Metal nanoparticles have been used extensively for chemical and biological sensing due to their unique optical properties known as localized surface plasmids resonances, LSPR. Gold and silver are two noble metals which have been widely studied for their plasmonic properties. These metals can be used to create nanoparticles with specific shapes and sizes, allowing for precise control over their optical properties. This review will discuss the synthetic methods available for creating AG nanoparticles, the coatings used to modify their properties, and the combination of gold and silver nanoparticles for plasmonic biosensing. Examples of AG and agio-based plasmonic biosensors will also be discussed. This article was authored by Alexis LaSau, Victoire Assela, Gabriel Boydolalon, and others.