 This study uses bibliometric analysis to identify global contributions in COVID-19 and vaccine safety, analyzing current status, development and research hotspots for future research directions. The results show that the USA, China and India are top contributors for scientific research on COVID-19 and vaccine safety, with the vaccine journal being the most productive. Li Y, Na Na and Li X were the top three prolific authors, while human, coronavirus disease 2019, and drug safety were the most common frontier topics. The findings suggest scaling up research and information dissemination on COVID-19 and vaccine safety. This article was authored by Dustin Yinka Akintund, Xiaojun Chen, Toha Hussain Musa and others.