 Anticancerapian drugs resistance is a complex process that arises from altering in the drug purposefully targets. The cancer cell cells resistance against the anti-cancer agents can be due to many factors such as the genetic differences, especially in tumoral somatic cells. The drug resistance can be occurred by different mechanisms, including multi-drug resistance. This article was authored by Bezod Mansuri, Ali Mohamedi, Sadaf Davudian, and others.