 The study evaluates knowledge, attitudes and behaviors of adolescents regarding vaccinations among a sample of 771 adolescents aged 11 to 18 from five public schools in Naples between March and May 2017. It found that 57.2 percent had fair satisfactory knowledge of vaccine preventable diseases, which was significantly higher in those who had at least one graduated parent, received information about vaccines from physicians or needed additional information. About 41.3 percent of adolescents had a very favorable attitude towards vaccinations, which was associated with the usefulness of information received an age of respondents. The study highlights the need for educational interventions to improve adolescents' understanding of vaccinations so that they can make informed decisions regarding their health. This article was authored by Conchetta Paola-Palulo and Gabriela Di Giuseppe.