 Travellers returning from international trips can experience a variety of gastrointestinal illnesses, including diarrhea, abdominal pain, bloating, and fatigue. These illnesses are often caused by bacterial or parasitic infections, which can be detected through molecular diagnostics. Polyabsorbable antibiotics and novel therapies like phage treatment could potentially help reduce the burden of antimicrobial resistance. Additionally, efforts to improve destination sanitation and hygiene infrastructure should be made to reduce the incidence of preventable illness in this setting. This article was authored by Dominic Butler, Ramona McLaughlin, and Gerard T. Flaherty.