 Salimerin, SM, and extract from the milk thistle plant has been widely studied for its liver-treating properties and is believed to act through various antioxidant mechanisms such as direct scavenging of free radicals, inhibiting specific ROS-producing enzymes, maintaining optimal redox balance in cells, decreasing inflammatory responses, activating Vita genes, and affecting the gut microenvironment. SM alone, or in combination with other hepatoprotective compounds, may have similar effects in animal nutrition and disease prevention strategies as described in Human Nutrition. This article was authored by Peter F. Surai.