 Acute appendicitis, AA, is a common cause of abdominal pain requiring surgery, with approximately 20% of cases involving complications such as gangrene or perforation. Diagnosis can be difficult and requires evaluation of clinical signs, laboratory index and imaging. Surgery is the best option for complicated AA, while laparoscopic treatment is recommended for uncomplicated cases. Postoperative antibiotic treatment is only necessary for patients with complicated AA. This article was authored by Eleonora Guaitoli, Guy Tomogallo, Eleonora Cardone and others.