 Abstract bromodomines, BDs, are a family of proteins that recognize acetylated lysines on histones and other substrates. They play important roles in gene regulation, chromatin remodeling, DNA repair, and cell proliferation. Recently, BDs have also been implicated in various diseases such as cancer, inflammatory disorders, cardiovascular disease, and viral infection. To combat these diseases, researchers have developed several compounds that target BDs, either by inhibiting their activity or by degrading them. This review summarizes the progress made in developing these compounds, focusing on their molecular structures, biological activities, interactions with BDs, and therapeutic potentials. Additionally, it discusses the challenges faced during the development process and the future direction of research. By understanding the mechanisms behind the development of these compounds, researchers hope to improve upon existing treatments and develop more effective therapies against diseases involving BDs. This article was offered by Xiaoping Pan, Yuxi Shao, Xiaoyan Wang, and others. We are article.tv, links in the description below.