 This paper proposes a new regulatory review model for South Africa, which is based on the parameters of the World Health Organization's global benchmarking tool, WHOGBT. The model includes quality measures, monitoring and evaluating review times, a risk-based evaluation, transparency and communication, and training in education. It also suggests ways to improve regulatory performance, such as strengthening reliance networks, reinforcing good regulatory practices, GRPs, and increasing transparency. If implemented, this model could lead to more efficient and transparent review processes, as well as increased consistency, evidence-based decision-making, and faster patient access to new medicines in South Africa.