 This paper aims to investigate the potential of biomarkers such as Prestin, Nox2, and Lipid profile in detecting sensorineural hearing loss, SNHL, in type 2 diabetes mellitus, T2DM, patients using a systematic study approach. The results suggest that these biomarkers may play a role in the early diagnosis of SNHL, but further research is needed to determine their effectiveness. This article was authored by Aga Santosa, Kutut Swastika, Maid Ratna Saraswasti, and others.