 The CBIO-plus approach is an effective and affordable approach that has been successful in engaging communities in the process of improving the health of their mothers and children and reducing health inequities in a marginalised, difficult-to-reach population of Indigenous Maya people. It is also cost-effective and merits further development and broader application in Guatemala and beyond. This article was authored by Henry B. Perry, I.I. Stollack, and Mario Valdez.