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Published on Apr 29, 2012
A very simplistic explanation of DNA hybridization is when a single-stranded DNA (ssDNA) molecule bonds with a complementary ssDNA molecule from another source forming a "hybrid". This animation shows a double-stranded DNA (dsDNA) molecule dividing into two ssDNA strands. One ssDNA remains on the substrate as the "probe". A complementary ssDNA from another source (a ssDNA with a complementary base pair sequence) joins with the probe forming a "hybrid" dsDNA molecule. This animation was produced by the Southwest Center for Microsystems Education (SCME). Supporting learning modules and activities can be downloaded from the SCME website (scme-nm.org).