 tinnitus is associated with abnormal functional connectivity of multiple regions of the brain. However, previous analytic methods have disregarded information on the direction of functional connectivity leading to only a moderate efficacy of pre-treatment planning. We hypothesized that the pattern of directional functional connectivity can provide key information on treatment outcomes. 64 participants were enrolled in this study, 18 patients with tinnitus were categorized into the effective group, 22 patients into the ineffective group, and 24 healthy participants into the healthy control group. We acquired resting state functional magnetic resonance images prior to sound therapy and constructed an effective connectivity network of the three groups using an artificial B-colony algorithm and transfer entropy. The key feature of patients with tinnitus was the significantly increased signal output of the sensory network, including the auditory, visual, and somatosensory networks and parts of the motor network. This provided critical insights into the gain theory of tinnitus development. The altered pattern of functional information orchestration represented by a higher degree of hypervigilance-driven attention and N. This article was authored by Han Lv, Jin Duolu, Chen Shen, and others. We are article.tv, links in the description below.