 Herzlich willkommen zum Nachmittagslot hier im Zelt. Wer von den anwesenden Hackern hat denn heute schon Koffein? Okay, welcome to this translation of this talk about caffeine. Vielleicht zwei Handvoll eigentlich alle. Wer hier in the audience has consumed any caffeine today? Basically everyone in the audience raised their hands. As caffeine is such an integral part of being in a hacker. I'm very happy to announce the next speaker who will talk about everything. You always wanted to know about caffeine or maybe didn't want to know. Hallo liebe Menschen. Hello and welcome. I'm glad you're here in this tent and not at the lake. I'm happy to be talking about caffeine today. And I'm interested in that and I'm consuming a lot of caffeine myself. So I was thinking this might be a very interesting topic, which is also interesting to a lot of you. So while I was preparing for this talk, I looked at my own caffeine consumption. And on the bottom you see the date and on the left side you see the amount of caffeine I was taking in. And right now, that might not mean a lot to you, but we can see later what this means actually. So here we are seeing what types of caffeine I was consuming. And I was consuming about 10 liters of caffeine and that's around 2,000 milligrams of caffeine. And my favorite drink was Miu Miu Marta Ginger. So, ich habe mit mir Flora Marta mitgebracht, was ich nicht in diesem Graf habe, aber ich kann es jetzt genießen. So, erstmal schauen wir uns an die Molekule. Ihr seht es hier, es ist kalt und es ist nicht sehr kompliziert. In der originalen Form ist es eigentlich nicht sehr interessant. Und wenn ihr schaut, sieht es aus wie Powder Chugger. Und ich denke, dass alle von euch wissen, wie es so aussieht. Und der erste verabschiedete Kaffeein war eigentlich von Kaffeebeins. Und Goethe war interessiert, was die Stimulierung des Kaffeeins ist, und er verabschiedete die Molekule. Und er war recherchisch über das. Die Kaffeein, das ihr seht, ist eigentlich das selbe wie Kaffeein. Manchmal hat es sich differenziert, weil es die Stimulierung des Kaffeeins ist. Aber der offizielle Chemistische Name hier ist 1,3,7, primatische, 3,7, dihydro, 1,H, Pukin, 2,6, Dion. Ich weiß nicht, was das offizielle Name für Kaffeein ist. Also, die am häufigsten bekannte Wirkung des Kaffeeins ist, dass sie uns wach macht. Also, wenn ihr schaut, was es ist, was wir tun und was die Effekte sind, das weltweiligste Effekt ist, dass es uns von Zehne wächst. Und das ist das, was wir meistens für alle benutzen. Und also, die Lieseldose der Kaffeein ist 10 Gramm. Und das klingt wie viel. Und in der dailyen Konsumtion wird es nicht so gut. Also, schauen wir, was der Effekt der Kaffeein ist. Und wir trinken es alle, weil wir glücklich sind und energisiert sind. Wir starten unsere Tage so. Und der Haupteffekt der Kaffeein ist... Also, der Haupteffektive Method, wie es funktioniert, ist, es geht zu den Rezeptoren der Adenosin in deinem Kopf. Und es kann deine Blattpressur und dein Herzschluss erhöhen. Es kann es einfacher für dich zu breatheen. Und es kann dich mehr effektiv machen. Es kann deine Konsumtion erhöhen. Es kann deinen Level erhöhen. Also, schauen wir uns, wie es eigentlich funktioniert. In unserem Gehirn haben wir alle diese Synapsen. Die Synapsen sind basically, wie das Körper reguliert, was wir an jeder Stelle brauchen und wie es funktioniert. Die Kaffeein geht, wo die Adenosin usually geht. Die Adenosin, die wir in unserem Gehirn haben, ist etwas, das von ATP, Adenosin Triphosphate, und wenn wir etwas benutzen, wir benutzen Energie in unserem Körper, was passiert ist, dass ATP in Adenosin geflogen ist, among andere. Und das kind of leads to me getting tired when I have a lot of Adenosin, like the cat here. The Adenosin makes sure that our body doesn't split out anymore, and it makes us tired. So, it's basically the opposite of caffeine. Okay? The caffeine basically goes to the transmitter, but instead of Adenosin, it doesn't do anything at this point. So, all of these things that happen when you're tired don't happen. So, instead we become more awake, we become more active, we become happy. And that also, the caffeine also works differently depending on how our body works. For older people caffeine works more, it goes to the proteins in your blood, and older people have less proteins, whereas someone who's smoking, they will eliminate the caffeine more quickly, because the enzymes that are eliminating the caffeine are higher concentrated in people who are smoking. And if you use contraception, hormonal contraception, or are pregnant, then it's completely the opposite. So, your elimination is smaller. It's also interesting that if you have ADHD, you might have a paradox effect of caffeine. So, and it was something that I found on the Internet, but I also found some research that would suggest this, because ADHD also works on the neurotransmitters, like Adrenaline. So, if we have something that makes sure, so if with ADHD you have something that leads to dopamine being more released, then this caffeine could also have a different effect. So, it's possible that it is, but we haven't really, there's not really a lot of evidence. So, if we consume too much caffeine, then we kind of get side effects. Now, when I take a matter, when I drink a matter, I might not be able to sleep. Now, if I actually drink too much, we can become nervous, we can not be able to sleep, we can sweat a lot, we can be kind of nervous, our heart rate quickens, and everything of that is like what happens when we're too awake. So, our body kind of feels we have too much energy, and this energy needs to go somewhere. So, maybe we even get panic attacks. Langfristig. Ein Entwicklung einer Toleranz. In der liest-series side effect, long-standing side effect, is actually that we get a tolerance. So, you get used to it, and your body will react if you don't give him the caffeine. So, let's talk about the mass of caffeine. So, what's much caffeine, what's little caffeine? So, actually the Federal Institute for Risk Taking Sie haben einige Guide-Line für die Adults, die sagen, dass du nicht mehr als 200 mg Kaffee mit einem Zeitung gehörst, das ist ein Clubmattes, und du sollst nicht mehr als 400 mg Kaffee pro Tag nehmen, also nicht mehr als 5,7 mg per kg Kaffee-Buddy-Weg. Du sollst nur 3 mg per 1 kg Kaffee-Buddy-Weg tun, weil Kaffee in der Zentral-Nervus-Systeme funktioniert, weil du nur 3 mg per 1 kg Kaffee-Buddy-Weg tun, per Tag eigentlich. Das ist ziemlich interessant für Kinder, die über 33 kg schwer sind, die können eigentlich nur 1 kg Kaffee-Buddy-Weg tun. Und wenn du verabschiedest, sollst du ca. 1,5 kg Kaffee-Buddy-Weg tun, also höchstens. Also nicht so, dass das Kind keine Probleme hat. In general ist es ca. 200 mg per Tag, was ich denke, ist sehr viel. Es gibt viele Ausreden, wenn die jungen Menschen Kaffee trinken, aber es ist eigentlich ihre Entscheidung, oder? Okay, Kaffee in der langen Zeit, wir werden neue Synapsen für Adenosine machen. Da ist unser Körper in Ordnung, so wird das Ganze Adenosine nicht abgebrochen. Also, wenn du mehr Kaffee trinkst, wird du mehr Synapsen, die sich abgebaut hat. Wenn wir viel schlafen wollen, müssen wir plötzlich mehr Kaffee trinken. Oder nicht mehr Kaffee trinken und dann warten für die Adenosine, um es zu erleben und zu schlafen. Also, was passiert, wenn wir keine Kaffee trinken, werden wir eigentlich zufrieden. Viele Menschen, die mich betrachten, dass Kaffee im Frühstück ist, sind wirklich toll. Wer von euch trinkt Kaffee, um die erste Stunde heute zu kommen? Unfortunately, wir werden nicht zufrieden und dann sehr fit wie dieses Kaffee. Wir haben einen Hormon in unserem Körper, Cortisol. Cortisol, in der Frühstück, hat eine Stunde, nachdem wir draußen sitzen. Da ist dieses Kaffee, und wir sind plötzlich weg. Wir können diese Situation nicht verbessern. Wenn wir das in den Montag machen, dann, in der Frühstück, unser Körper wird denken, ich muss das Cortisol nicht produzieren. Das führt zu unserem Körper, basically, uns zu erwarten, um Kaffee zu trinken. Also, bis nach einer Stunde nach, du musst nicht Kaffee trinken, bis zu einer Stunde nach, nachdem du getroffen bist. Hier, ich sage, zwischen 8 Uhr und 9 Uhr, und das assumes, dass du am 8 Uhr kommst. Wer heute, wer von euch, oder davor ausgeführt hat, heute oder am 8 Uhr oder früher? Oh, ganz viel, eigentlich. Ganz überraschend. Jedenfalls haben wir... Okay, anyway, zwischen 12 und 13, zwischen 12 und 1 pm, wir haben auch ein Cortisol-Pik, und zwischen 5.30 und 6.30 pm, also, wenn du Mathe mit dir hast, trink es jetzt. Also, angenommen, wir sind jetzt an dem Punkt, an dem wir... Angenommen, wir sind an dem Punkt, an dem wir keine länger Kaffee trinken wollen. Und dann sind wir in den Fondern der Mathe, und wir haben das, und vielleicht wollen wir es nehmen, aber vielleicht, wenn wir es nicht tun, sind wir eigentlich im Strahl, das ist das Minimum von 12 Stunden, und es kann bis zu 9 Tagen sein, bis zu 2 Tagen, und es führt zu Headaches, und wir sind traurig, wir verlieren Energie, wir sind müde, wir sind nicht so glücklich, als in diesem Punkt, vielleicht haben wir auch einen erhöhen Appetit, das ist, weil Kaffee uns energisiert, und es geht runter, wenn wir es stoppen, und man kann auch Trouble-Sleeping haben, und wir haben das Studie from 2003, which describes all the effects, which happened, if you stop taking caffeine, and there was also no nightmares, actually. And there is also this funny website on the internet, where you can check your dose for caffeine, which is from the official Bundeszentrum for the official German who is trying to tell us what is healthy for you and what is not, so I clicked around on this webpage, and you can select how much caffeine you are taking, and what's your age and your body weight, and the time span where you drank it, and whether you drank it all at once or throughout the day. And you can choose a couple of drinks here, for example black tea, green tea, coffee, espresso, chocolate, which you eat. So I clicked around there a bit, and I was like, what is happening here, what is calculating. And I got a lot of different results here, so I was kind of interested and I looked at the source code and found javascript. So that's kind of interesting, because it's kind of inconsistent, the code, also, because the numbers of how much caffeine is in there, there is sometimes the concentration per 100 Milliliters, Milligramm pro 100 Milliliters, which is Milligramm per 100 Milliliters, and in other cases it's per cup, which I find kind of weird, because a cup is a defined unit, so it's not really clear how much it actually is. Also, it doesn't include whether a person is above or under 18, so there is different variations as a calculation. I'm sorry, I didn't format the code here correctly, if you're very interested in it, you can look at the code yourself, and also there is a randomization of the responses. So, if you're on the edge, you can get a note saying attention or this is at the edge, so it's kind of funny, actually. Also, as this website is talking about, sometimes it can be too much caffeine, so let's talk about the desolate dose of caffeine, which is far away from 400mg, we were talking about earlier, which is 10g, 10 whole grams. So, the question here becomes, where is caffeine in the things we consume? So, if I look at this Floramate, that's around 100mg of caffeine, so that would be a lot of Floramate. So, I went to my headspace and looked at the fridge and I looked at the Martefridge and we have also drinks like beer because that's like a basic thing we also have and we also have drinks without caffeine and so I started looking at what kinds of drinks we have there and in our storage we have 137l of Martefridge and I was looking at how much caffeine is in the different types of Martefridge and it's 27.65g of caffeine and I also looked at the fridge which is 28l of Martefridge which concludes to 5.7g of caffeine so in total that's 165l of Martefridge and 33.43g of caffeine so that would be 55l of Martefridge for a lethal dose of caffeine that would be a lot to drink the body will shut this down not just because of the caffeine but for a lot of other reasons so getting an overdose of caffeine an accident is super difficult so another question is where else do we find caffeine because obviously we can drink Marta and we can do coffee but are there other stuff like foods we consume which include caffeine and I walked around by a flat and saw what I could find and I found chocolate where you might be surprised to find caffeine so here we have a list of stuff you might usually consume where you find caffeine so the thing I personally find most interesting is chocolate but to get to these numbers I can actually drink a lot of Marta I'm more happy to drink a Flora Marta than eat 5 milk chocolate even though that would also be nice coffee is kind of a special case it depends on how strong the coffee is last year at GPN which is another hacker event we had a coffee machine and we filled it up to the limit so it barely closed so that was maybe a bit more caffeine but in other cases if you put less coffee in your coffee so less coffee powder in your coffee then it might be a bit weaker but just looking at the laws there are also limits so there is this limit of 15 mg per 100 ml and there is this warning which is saying not for children but for pregnant people and this is because of the laws which are telling the producers to put this label on their products and a lot of companies actually put this label on drinks where they don't need to but they are doing it anyways and for energy drinks there is actually a different limit und for energy drinks it's a maximum of 32 mg per 100 ml and there is also special caffeine-nated products so food which would not include caffeine on its own or stuff which have additionally added caffeine for example this koa watch there is also jellies or especially caffeine-nated chocolate which has more caffeine than regular chocolate there is chewing gums there is caffeine tablets caffeine tablets actually I am actually studying chemistry one person there is eating caffeine tablets with red wine but especially with caffeine tablets actually go to your limits a little bit it's not quite lethal most of the time but it can become dangerous 80 mg 100 ml so a regular coffee is like 80 mg per 100 ml but some coffee beans are actually stronger in caffeine than just regular ones 85 ml where you can easily get to 58 mg per 100 ml but isn't a ton but it's getting more and there is this black insomnia coffee which is the strongest coffee I could find which is 311 mg per 100 ml and it was a bit confusing to find this out because a lot of the producers are saying this amount of caffeine per cup and as I just talked about earlier a cup is not the best unit of measurement because there are tiny cups and small cups so that can mean a lot of things if you put this measurements by cup and at some point I found out a cup is 177 ml which is from the US because they don't like metric measuring systems and another thing you might have heard about is caffeine against hair loss which is like hey, caffeine can help my body but can it also help my hair and can my hair grow stronger or better or faster or is there any kind of cool effect und there is actually studies on this which have a positive effect in the laboratory which is for a specific case for hair loss due to genetics and for people who have this special genetic case they make testosterone and caffeine and put the substance in there and so they put the hair in there for five days and I don't think most of us actually wash their hair five whole days in the UK there is a shampoo which has been limited to advertise they were advertising for this to reduce hair loss but they were limited to do this advertising because there is not really a scientific proof here and then I was also asking myself how much caffeine do we consume worldwide und I found a lot of stats about coffee so I specifically looked at these stats about coffee which I could find I found out in Finland people consume a lot of coffee and a lot of Scandinavian countries are doing quite well Germany is kind of in the middle here und this is 2017 sorry for 2017 but it's not the stats in Finland und in Sweden gibt es so eine Art von Kaffeepause also es ist auch in Finland there is this concept of Fika which is kind of a coffee break but it's not just a coffee break we know which is just like taking coffee also form a socializing so due to this Fika this is a reason why there is this high consume of coffee in the Scandinavian countries in Iceland it's apparently the national drink but I didn't really find stats on this and apparently coffee is not only known on our planet but also on the USS Voyager where the captain is flying to different kinds of planets to find more coffee and I was like yeah well coffee is alright but I myself don't consume a lot of coffee so I prefer mate and how is the consumption for mate worldwide mate the original substance is from South America but the iced tea we have here is originating in Germany which was known as Zektpronte which is produced by Brewerie Loscher and we could actually visit the mate brewery at the international club mate party and this brewery on their website is saying they export to 75 companies worldwide to Madagascar and China so maybe club mate is being exported worldwide and I think this is mostly specific for club mate I'm currently talking a lot about how much coffee and how can we measure this and it would be kind of cool to have some sort of fluid or something else that would allow us to find out how much caffeine is in there so like a lapmus test basically that would be amazing but unfortunately it's not that easy there is a murexit test which allows us to to find coffee basically but unfortunately we can also find other stuff like urea and it's usually it was found to find urea actually so if you look for if you use this test then you can actually find urea in your urine but unfortunately it's not very easy to actually carry it out because you need very specific chemicals and then it becomes violet once you find it and then we also don't know what is the limit for finding it so maybe we can't even find our caffeine so that would be an easy solution because caffeine is in there so the good answer is there is a possibility but it's not very easy there is a lab HPLC which is like a high power liquid chromatograph which which allows a lot of chemists to not have to work as much basically I have some stuff in there and then just easily just very basic sorry I haven't found a picture of a more more recent OS I've already stood in front of this device at university and I think I kind of just tried to forget what kind of OS there was because those devices are very expensive they just use whatever OS works with this software so basically what this does is it separates it separates stuff and there's an experiment that schools like to do so we use a filter paper and put a hole in there in kind of allow this paper to be separated into its this pen to be separated into its constituting elements and this is the same thing we do with this HPLC we have one matter and we modify it a little bit so in order to do that we use solutions and one of them is a calibrating solution and because for this calibrating solution we actually know the concentration of whatever active ingredient we want to test for and this is what we use for our internal standard so this internal standard is something that is similar to the stuff that we want to analyze which allows us to make sure that we don't make as many mistakes basically and if anything in this internal standard changes then we know that our actual stuff is also probably changing so if we use something that is similar to the caffeine then we have suddenly done this with this calibration solution wie genauso at which point we have this solution of whatever with caffeine and then this allows us to separate this solution into different smaller solutions and sometimes we can use different methods as well where molecules are split apart what is actually in these molecules and it's actually quite a complicated topic but the idea is we separate this into different molecules and then we are able to see what is in there okay so this was it I hope you've learned something about caffeine I'll upload these slides later so if you have any questions just ask them right now thank you for your attention okay vielen Dank soweit Lea thank you Lea we have about 13 minutes for questions and answers if you have questions just head up to the microphones there's one on the left and one on the right and we'll be able to answer your questions or Lea will be able to answer your questions there's no questions apparently okay wenn wir noch Zeit haben was ist eure Lieblingsmarte Sorte okay was ist euer Favorit was ist euer Favorit Marte mal ganz kurz also es gibt ja eigentlich 1-2 auf dem Kongress wer mag denn Flora Power lieber mal kurz Handtuch Hands are shown who prefers Club Marte das ist relativ gleich roughly unanimous maybe a little more Flora Power who prefers another kind of Marte Ich sehe schon. Wir müssen irgendwie an der Mate-Pluralität auf dem Chaos weitermachen. Wir haben noch eine Frage gefunden, bitte schön. Es gibt immer das Gerüchtlich, weil ich habe noch nie einen Rumor, dass man, wenn man irgendwie nur eine Woche oder so, kein Koffein, wenn man diese Toleranzgeschichte für eine Woche hat, dann wird die Toleranz bis zero, also in einer sehr, sehr kurzen Zeit. Ich kann mir vorstellen, dass es eine sehr kurze Zeit ist, weil die meisten Wichtdrahtsymptome sind dann, also, in zwei Tagen. Natürlich kann es manchmal etwas länger dauern, aber es ist nur zwei Wochen. Also, nach neun Tagen, wenn man die Wichtdraht ist, dann wird es nach neun Tagen sein. Also, ja, die Entzugserscheinung ist dann weg, aber die Frage wäre, du hast ja gesagt, es bilden sich dann noch mehr Nervenzellen und Synapsen. Yes, the withdrawal symptoms are done, but the synapses are... What about the synapses that have? Meine Idee ist, also, diese Synapsen... Appear. Well, yeah, of course, someone else can say something, but maybe my idea is that these synapses are kind of appearing very quickly, so they might be able to disappear very quickly as well. Sieht nicht so aus, vielleicht... Okay, doesn't look like it. Maybe next Congress, they will follow up. Wie gesagt, ich bin nicht der weißte Letzter Schluss, wenn ihr irgendetwas findet, womit ihr mich über Koffein genau informieren könnt. Bitte her damit. Also, ihr könnt mir auch sehr gerne Nachrichten über Koffein schreiben, wenn ihr das möchtet. Like, I'm not the only expert here. If you have any more information about caffeine and you want to inform me about this, just send me a message. Thank you, Lea, for this talk.