 This study assessed the world health organizations, WHO, Integrate Framework, which was developed to support guideline development from a complexity perspective. The study found that the framework was well received by health decision makers and developers of who guidelines. It also identified areas for improvement, including clarifying the meaning of certain terms and criteria, and providing guidance on how to apply the framework and guideline processes that are both transparent and participatory. This article was authored by Jan M. Straddle, Deepak Padel, Karan Isetti, and others.