 This study found that college students in Eldorette Kenya are more likely to engage in substance use if they have high levels of neuroticism and low levels of agreeableness. These findings suggest that personality traits may be important factors in determining whether someone will become addicted to substances. Further research should explore how personality traits influence substance use and how these traits can be used to develop effective interventions. This article was authored by Daniel Wagonjo-Kinyanjwi and Nwangi Sum.