 NAMASKARA Nannisro Dr. Mallika Arjun Kalishtiyanta I am a consultant hematologist hematoconcologist and bone marrow transplant physician at Manipal Hospital Bangalore So bone marrow transplantation is a very intense medical procedure So it is really because of the conditioning chemotherapy some patients will have severe nausea severe omitting we call what is called as mico-satisandre TUMBA NOVA GUTHARGEE YENADRU AHARA SWALOMONDLUKUSA their blood counts will drop so the condition of the patient will be very high the blood pressure will be very high many of them will require transfusions blood cell transfusions platelet transfusions will be needed all these transfusions will be special transfusions wherein we will have to irradiate blood products so that they don't have the risk of transfusion associated graft-corsus-host disease they will lose hair some patients may have other organ toxicity there may be ill effects on other organ systems and rarely patients will develop such severe mico-satis mico-satisandre there is so much conditioning chemotherapy overall mico-satisandre they will not be able to digest food so we may have to give them total parental nutrition many patients feel extremely fatigued so it is not an easy procedure initially few days while they are in bone marrow they may have many of these issues long term there is one particular complication that we must always talk to patients before they go for transplantation in allogenic bone marrow transplantation that is what is called as graft-corsus-host disease graft-corsus-host disease in the stem cells there is a very healthy donor when they are matched those cells may mount an immune attack in the host body that cell is a recipient they may start attacking which is called as graft-corsus-host disease this is called as acute graft-corsus-host disease after 100 days this is called as chronic graft-corsus-host disease that is because of the underlying disease and because of various chemotherapy many of these patients will have received and also because of the conditioning chemotherapy our immunity is very strong so they may develop multiple infections and any minor infection can become life-threatening so post bone marrow transplantation for about 3-6 months the immune system of the patient is not robust and they are prone for all kinds of infections