 Hi. My name is Dr. Emily Oates and I'm a clinical geneticist who works predominantly with patients and families impacted by genetic nerve and muscle disorders. I'm also a nearly career researcher and head the University of New South Wales Medical Genomics Research Team. I am so incredibly grateful to the Brain Foundation and its donors and sponsors for funding our Assessive Titanopathy Muscle Analysis Project. Assessive Titanopathy has recently emerged as one of the most common childhood onset genetic muscle disorders. It results in really significant physical disability and sometimes early death, and there are no effective treatments. Our current Assessive Titanopathy treatment development work, focusing on CRISPR on and exon skipping approaches, has shown early promise. But this work has really been hampered by the lack of an effective means of measuring Titan protein expression within muscle. This project will directly address this issue by allowing us to develop a new mass spectrometry based method to measure Titan within muscle samples from both patients and controls. This will give us a much better idea of how much additional Titan expression at the protein level is needed to improve patient outcomes. I'm so excited about the potential impact of this project in terms of understanding this condition and enabling us to develop effective treatments for our patients. And I'm so grateful to the Brain Foundation for funding this work. Thank you.