 Complementary and alternative medicine, CAM, has become increasingly popular in recent years due to its potential to treat various diseases. Patients with serious conditions like cancer, Alzheimer's, diabetes, and lower back pain often turn to CAM biological products for relief. Healthcare professionals must be aware of the available clinical evidence regarding CAM-based therapies before advising their patients or making recommendations. This paper reviews the recent clinical data on the efficacy of CAM therapies for managing certain diseases. Several cancer drugs derived from natural sources have recently received approval from the European Medicines Agency and Food and Drug Administration after successful clinical trials. Additionally, the most commonly used CAM therapies and the degree of improvement in quality of life reported by patients are discussed. This article was authored by Al-Jawara Al-Kathima.