 The study examined the role of secretase in Alzheimer's disease. It found that the absence of all three AF1 subunits in the pyramidal neurons of the postnatal forebrain leads to progressive cortical atrophy, neuronal loss, and gliosis. Additionally, it showed that the accumulation of membrane-bound fragments of APP, APLP1, NRG1, and DCC is increased in these mice compared to wild-type controls. However, the removal of APP did not prevent the neurodegenerative effects of the mutant mice. Instead, the researchers suggest that selective AF1 gamma secretase inhibitors could be used to treat Alzheimer's disease.