 Human social genomics is an emerging field that examines how social experiences influence our genetics and ultimately our health and well-being. It looks at how both positive and negative experiences can alter gene expression, leading to long-term health outcomes. This review summarizes common patterns of social influences on gene expression, as well as the psychological, neural, and cellular mechanisms through which social experiences can affect gene expression. Additionally, it explores how genetic polymorphisms moderate the effect of social experiences on gene expression, and identifies positive psychosocial experiences and interventions that have been shown to impact gene expression. Finally, it discusses potential applications of this knowledge for improving patient health and well-being. This article was offered by George M. Slavik, Summer Menzelcock and Stephen W. Cole.