 Metabolic syndrome and its components are associated with chronic kidney disease, CKD. Insulin resistance, IR, plays a central role in the metabolic syndrome and is associated with increased risk for CKD in non-diabetic patients. IR is common in patients with mild to moderate stage CKD, even when the glomerular filtration rate is within the normal range. IR, along with oxidative stress and inflammation, also promotes kidney disease. In patients with end stage renal disease, IR is an independent predictor of cardiovascular disease and is linked to protein energy wasting and malnutrition. Systemic inflammation, oxidative stress, elevated serum adipokines and feteurin A, metabolic acidosis, vitamin D deficiency, depressed serum erythropoietin, endoplasmic reticulum stress, and suppressors of cytokine signaling all cause IR by suppressing insulin receptor, PI3K, act pathways in CKD. In addition to adequate renal replacement therapy and correction of U. This article was authored by Minit Sir Liao, Chichi N. Sung, Quichin Hung, and others. We are article.tv, links in the description below.