 The authors have developed a new nanoscale metal organic framework, MOF, called TZM, which can be used in conjunction with X-rays to enhance the effectiveness of radiotherapy, RT, and anti-tumor immunity. This MOF has been shown to absorb X-ray energy and transfer it to a photosensitizing agent, allowing for more effective killing of cancer cells while also stimulating the body's own immune system to fight against the tumor. Additionally, this MOF has been found to be particularly effective when combined with other treatments such as immunotherapies or drugs targeting PD-L1, further enhancing its potential to combat metastatic osteosarcoma. This article was authored by Tau Li, Minkuan Gao, Zifei Wu, and others.