 This study examined the effect of various factors on the survival rate of patients admitted to an intensive care unit, ICU, due to SARS-CoV-2 infection. The results showed that the mortality rate was higher among patients infected with the alpha variant compared to those infected with other variants. Additionally, the severity of illness as measured by the simplified acute physiology score, saps 2, on day 1 of admission was also found to be associated with mortality. Furthermore, the use of rendicevir, a drug used to treat severe cases of COVID-19, was found to reduce the risk of death. Finally, the presence of acute kidney injury, aka, gastrointestinal failure, sepsis, and white blood cell count were all found to be associated with increased mortality. This article was authored by Athena Lavrentiva, Evangelo's Chimacarmes, Vasileo's Vauxes, and others.