 The study evaluated the efficacy and safety of the novel combination therapy consisting of low-fluence Q-switched 1064 nanometers ND, YAG laser, hydroquinone cream, and oral tranhexamic acid for recalcitrant reels melanosis in eight Asian patients. The results showed that three patients achieved almost clear grade, while the other five patients received marked improvement grade at final visits. No serious adverse events were observed, and mean melanin and erythema indexes showed significant decreases compared with baseline. Histopathologic examination confirmed a significantly greater reduction of melanin content in melanophages. Therefore, this combination method can be a viable option for Asian patients with reels melanosis at high risk of post-inflammatory hyperpigmentation while maintaining low-dose laser irradiation. This article was authored by Hyakoon Kwon, Jung Yun-won, Dae Hun Soo, and others.