 This systematic review and meta-analysis found that mRNA vaccines were associated with fewer serious adverse events compared to other types of vaccines, such as viral vector and inactivated vaccines. However, there was no clear evidence that these vaccines directly cause serious adverse events. Additionally, mRNA vaccines were associated with a lower risk of SARS-CoV-2 infection than other types of vaccines. Overall, the findings suggest that mRNA vaccines may provide better protection against SARS-CoV-2 infection than other types of vaccines. This article was authored by Yu Jing-Fan, Kwak Hong-Chan, and Ivan Fan-Nai Hung.