 The study aimed to assess the non-inferiority of telehealth versus in-person visits among adolescents and young adults, AYA, and their parents and caregivers, caregivers, by comparing acceptability with respect to efficiency, effectiveness, equity, patient-centeredness, and confidentiality. The results showed that telehealth was highly acceptable among AYA and caregivers, with most rating it as non-inferior to in-person visits with respect to confidentiality, communication, medication management, and mental health care. However, concerns were raised about reduced safety and effectiveness of care for patients with eating disorders due to lack of hands-on examinations, collection of vital signs, and laboratory testing. The study suggests that future optimization should include improving privacy, ameliorating technical difficulties, and standardizing at-home methods of obtaining patient data to assure patient safety. This article was authored by Sarah M. Wood, Julia Pickle, Alexis W. Phillips, and others.