 The simulation framework developed by the researchers can be used to determine the most cost-effective survey designs for decision-making and STH control programs. The results show that deploying a duplicate CatoCat's thick smear on a single stool sample is the most cost-effective way to stop preventive chemotherapy when the prevalence of infection is below 2%, while a single CatoCat's thick smear is the most cost-effective method to declare the elimination of STHs as a public health problem when the prevalence of moderate to heavy intensity infections is below 2%. This article was authored by Adama Kasianga, Brinolovac, Gemachita Deslita, and others.